Sarah Wayne Callies is an American actress who is best known for her role as Sara Tancredi in the American television series Prison Break. She now plays Lori Grimes in The Walking Dead.

Callies was born Sarah Anne Callies in La Grange, Illinois. She moved to Honolulu, Hawaii with her family when she was one. Throughout her youth, she expressed an interest in acting through participating in various school plays at the independent Punahou School.

While her parents are professors at the University of Hawaii, Manoa, Callies did not follow in their footsteps. Instead, she chose to pursue a career in acting. After graduating from high school, she entered Dartmouth College in Hanover, New Hampshire. In conjunction with her studies, she continued her involvement in theatre. She continued her education at Denver's National Theater Conservatory where she obtained her Master of Fine Arts degree in 2002.

Callies' first role on television was as Kate O'Malley, a recurring role on the short-lived CBS show Queens Supreme. Her first starring role was as Detective Jane Porter on The WB's Tarzan.

After making various guest appearances on Law & Order: Special Victims Unit, Dragnet (2003) and NUMB3RS, Callies gained a starring role on Fox's Prison Break as Sara Tancredi. Her role lasted from 2005 through 2009. According to Prison Break's executive producer Matt Olmstead, although he, the writers, the network and Callies herself all wanted her to stay on the show the character was written out related to contract disputes.

However, in March 2008 Olmstead stated that the character of Sara is still alive and would return in Season 4 of Prison Break. Though the character Sara Tancredi appeared to have a violent death Olmstead stated "...we realized that there was actually a way she could still be alive." When asked by Kirstin of E! whether the fans' overwhelming response to her death (namely the STGD Campaign and Save-Sara-Tancredi.org) had factored in, Executive Producer Matt Olmstead admitted it had indeed influenced the decision.

Callies has also starred in two feature films - Universal Pictures' Whisper and an independent film, The Celestine Prophecy.

In April 2010, she appeared on the Fox Television drama House MD as a patient of the week whose open marriage fascinates House and the team.

She portrays Lori Grimes in the horror/drama series The Walking Dead, based on the graphic novel series of the same name. Callies played one of the female lead roles in the upcoming Canadian thriller Faces in the Crowd. In August 2010 Callies' first screenplay, an adaptation of Campbell Geeslin's children's book "Elena's Serenade", was optioned by producer Cameron Lamb and Canadian production company The Film Farm.

On June 21, 2005, Callies married Josh Winterhalt, whom she met at Dartmouth College. Winterhalt is a martial arts teacher. On January 23, 2007, her publicist announced that the couple were expecting their first child. In July 2007, Callies gave birth to a girl, Keala Winterhalt. She is close friends with Prison Break co-star Wentworth Miller saying: "I have the great privilege of working opposite someone who is also a great friend. That's something that makes my work easier, it makes my time on set more fun and I think it makes the work better". She was voted one of Maxim's "The Hottest Women of Fall TV '08."