Lillix released their debut album Falling Uphill in Canada and the United States on 27 May 2003 and in Japan on 27 August 2003. The single releases for this album were "It's About Time", "Tomorrow", and "What I Like About You", which is a cover for the eponymous song by The Romantics. This song is featured on the 2003 Freaky Friday soundtrack, and is the theme song for the comedy series What I Like About You. By the time of the album's release, Urhahn had replaced Hills as drummer. The band received two nominations at the 2004 Junos.

The second album, Inside the Hollow, was released in Canada on 29 August 2006 and in Japan on 6 September 2006. The only single from this album is "Sweet Temptation (Hollow)". This album's release saw another change in drummers, with Warrington taking the seat in October 2005 after Urhahn departed. This is also the first album which features tracks written by Scott Thompson.

Preceding the release of Inside the Hollow, Louise Burns stated that because Maverick Records had folded, the album would only be available in Japan and Canada until further notice. After the revelation that Warrington had departed the band at the end of October 2006 and that Burns is now affiliated with The Luna Riot, it was confirmed by Lacey-Lee Evin that the band had decided to "take a break", and that no further album releases were expected.

In April 2007, it was announced on the band's website that two new members had been located, bass player Ashley Grobell and drummer Eric Hoodicoff, and that the band was in the process of rebuilding. As of June 2007, the group's MySpace page no longer listed Grobell as being a member of the band, listing bassist (now lead guitarist and writer) Scott Thompson in her place. In April 2008, Scott Thompson announced he has also decided to leave the band with a blog on myspace about it. The band now has Britt Black as their guitarist, an artist who joined after having conducted a solo career.

On 14 July 2007, the band performed at the Nakusp Music Festival to sold out crowds.

In April 2008, a few days after Thompson announced his departure, the band said they are moving to Vancouver, BC and will be getting ready to record a new album.

On 15 March 2009, the band announced on its Myspace blog that it was reforming. The band introduced a new member, Britt Black, and announced the recording of a new single, "Dance Alone," which can be listened to on their official website. In addition, the band launched pages on Facebook and Twitter and announced the launching of a new website.

The groups label site Lillix.com shut down after the girls were dropped; however, their official music site Lillix.net remained opened, but not updated. In 2009, the group's old official site Lillix.net was updated and re-directed to LillixOnline.com, and announced the new single "Dance Alone".