Jeremy Sisto is an American actor. He was born in Grass Valley, California, the son of Reedy Gibbs, an actress and farmer, and Richard Sisto, a farmer, jazz musician and educator; the two divorced in 1980 and his stepfather is also an actor. He has an older sister, Meadow, who got him involved in acting. He grew up in Chicago, Illinois, attended the progressive Francis W. Parker School and appeared in the movie Grand Canyon while attending high school at Parker. After studying at UCLA he started acting full time.

When he was young he appeared in the Twisted Sister video "We're Not Gonna Take It". Sisto has played various different characters in a quite impressive and still expanding number of movies. He played, for instance, a killer in Hideaway, a rich spoiled brat in Clueless and White Squall, Jesus and Julius Caesar in the eponymous mini-series, a patient diagnosed with Multiple Personality Disorder in Inside, a former drug addict in Thirteen, and an abusive husband in Waitress. Furthermore, Jeremy made a name as Billy, the brother of Brenda Chenowith, in the HBO series Six Feet Under.

Besides acting, Sisto discovered a new interest in working behind the scenes. In 1998, he produced the (unreleased) movie Taken, together with his friend Ethan Embry. Additionally, he made movies such as Three Women of Pain and Paranoia 1.0. In April 2003, he started his own production company, Dima Entertainment. He also appeared as an abusive boyfriend in The Heartis Deceitful Above All Things, a 2004 film about a troubled life between a boy and his biological mother.

In 2006, he appeared on Broadway in Festen. In the same year, he starred in the short-lived NBC drama series Kidnapped.

In 2008, Sisto joined the cast of the crime drama Law & Order as Detective Cyrus Lupo, replacing the outgoing Milena Govich. Sisto had previously appeared on the show as a lawyer in the previous season's finale. He also provided the voice of Batman in the direct-to-video movie Justice League: The New Frontier.