Holly Weber was raised in Redlands and the California desert with her two older siblings, Ricky Weber and Melissa Weber. Her parents divorced when she was 5 years old and she lived with her mother in Costa Rica, then she moved several times until her senior year in High School.

Weber's undergraduate education was funded by her GoGo Dancing at popular venues in Hollywood and Las Vegas. During this period she had braces applied to straighten her teeth and she began pursuing a degree in Orthodontics. Upon removal of the devices, her modeling career began and quickly flourished as she appeared on the covers and pages of over 25 different calendars, being featured in magazines such as Glamour, Muscle and Fitness and FHM.

Weber's acting career included many featured roles in music videos, most notably in Daize Shayne's Naughty Girl. Her television roles include appearances with Bon Jovi in Las Vegas, Kid Rock in CSI: NY, Jenny McCarthy in Party at the Palms and Denise Richards in Sex, Love & Secrets. Other popular shows she has appeared in include The Tonight Show, Bones, Threshold, Everybody Hates Chris, Two and a Half Men and many programs new to 2007 Cavemen, Big Shots, Life and Disney’s Wizards of Waverly Place.

Holly has filmed several Motion pictures, including Ron Howard's Frost/Nixon, Adam Sandler's You Don't Mess with the Zohan and Click, and she was also featured in Supergator and Room Service.