Facundo Arana was first taken to an acting class by a friend at the age of fifteen. Soon after, Arana was diagnosed with cancer. Facundo Arana spent most of 1989 fighting that disease; he would then be on a medical alert until 1994, when he was finally declared to be free of Hodgkin's disease.

Arana had begun performing small characters in Argentine soap operas since 1992. At the time, however, his life evolved more around the cancer that he had previously had, and that could have reappeared.

Unknown to many of his fans, Arana is also a musician, having studied saxophone. While he struggled to get important acting jobs at Telefe, he met a street musician and the two became friends, with Arana performing on the Buenos Aires streets for many months. In 1995, Arana finally got a break in his acting career, getting a small character in the national hit Perla Negra (Black Pearl), where he got the chance to act with Andrea Del Boca. In 1996, he acted in another soap opera, named Sueltos (Loose).

His participation in Montaña Rusa, Otra Vuelta (Lets go for Another Round on the Rollercoaster) a teenager-oriented soap opera, paved the way for Arana to be chosen as Alejo in Chiquititas (Tiny Angels). At the same time, he worked with the also well known Argentine actor Gastón Pauls in a play named El Rafa.

During 2000, Arana and Malena Solda played a romantic couple in another television series, Buenos Vecinos (Good Neighbors). He had participated alongside Gianella Neyra in a show named Yago, Pasión Morena (Yago, Dark Passion), just prior to acting with Solda in Buenos Vecinos.

During 2001, Arana filmed his first movie. La Fuga (The Escape) was a mega-hit in Argentine movie theaters.

During 2006, he acted in the hit telenovela Sos mi vida with his former co-worker Natalia Oreirofrom Muneca Brava. In January 2007 Facundo ended the telenovela with huge success.

On Saturday, May 10 2008. Facundo Aranda welcomed his first child, a daughter, India Arana. with his partner Maria Susini.