Feldman was born in Calabasas, California and is 5' 10" (178 cm) tall. She did print campaigns for Rampage, Jaguar, Fila, Wella, Zanetti for Italy, Diesel and Tornado in Israel, Panasonic in Japan, and Platini Jeans in North and South America. She also starred in television commercials for Panasonic Viera, Halifax in Great Britain, and a recent Movietickets.com spot, as well as a few music videos, such as Justin Timberlake's "Senorita" and Sugar Ray's "It's So Easy". Donna was featured in Maxim Magazine's annual Hot 100 List of 2005 as #84, and she was the awards hostess for the 2005 Academy Awards.

In 2005, Feldman became a model on the first season of NBC's new game show, Deal or No Deal. She held case 22 for most of the season. After the first season, Donna made the choice to leave Deal or No Deal when she became a cast member of My Network TV's primetime soap Fashion House, playing temptress Gloria which began airing on Sept 5, 2006. Fashion House is currently airing in over 50 Countries. She was featured in a layout in the February 2007 issue of Stuff. Donna is on April 07' cover of Women's Fitness RX Magazine.

Feldman also was on the December 6, 2006 episode of the Tonight Show with Jay Leno as a part of a Christmas Jaywalking segment. On July 2007, Donna is officially placed on the "100 Sexiest Women in the World List", coming in at # 17 in FHM South Africa August 2007. Donna stars as lead seductress/vampire in Enrique Iglesias new music video titled "Tired of Being Sorry". In 2008, Feldman had a supporting role in the Adam Sandler film You Don't Mess with the Zohan.