Dita Von Teese is well known for her fascination with 1940s cinema and classic retro style. This began at a young age and was fostered by her mother, who would buy clothes for her daughter to dress up in. Her mother was a fan of old, Golden-era Hollywood films, and it was from her that Von Teese developed a fascination with the actresses of that day, especially Betty Grable, an actress that she frequently cites as her favorite.

She was classically trained as a ballet dancer from an early age, and danced solo at age thirteen for a local ballet company. Though she originally wanted to be a ballerina, Von Teese states that "By 15 I was as good as I’d ever be". She was later to incorporate this element into her burlesque shows, where she frequently goes en pointe.

At age twelve she moved from Michigan to Orange County, California with her parents and her two sisters. Von Teese attended University High School in Irvine.

She worked in a lingerie store as a salesgirl when she was fifteen, and eventually as a buyer. Von Teese has been fond of wearing elaborate lingerie such as corsets and basques with fully fashioned stockings ever since. In college Von Teese studied historic costuming and aspired to work as a stylist for period films. She is a trained costume designer.

Von Teese began her career in a local strip club when she was eighteen. Disappointed with the lack of originality in all the other strippers' acts, Von Teese created a vintage-inspired outfit, with beehive hairstyle and elbow-length gloves coupled with a basque and seamed stockings, piquing the interest of the clientele.

It was during this time at the strip club that she began some glamour modeling, before she eventually became a fetish model. Her retro pin-up look, frequently emulating Bettie Page in photo shoots, set her apart from most other fetish models.

Von Teese is best known for her burlesque routines and is frequently dubbed "the Queen of Burlesque" in the press. Von Teese began performing burlesque in 1993 and, as a proponent of New Burlesque, has helped to popularize its revival. In her own words, she "puts the tease back into striptease" with long, elaborate dance shows with props and characters, often inspired by 1930s and 1940s musicals and films.

In recent years, the fashion world has come to accept Von Teese and her retro look, and she has appeared on a number of best-dressed lists. Von Teese frequents the front row of fashion shows, particularly Christian Dior and Marc Jacobs, labels she is often seen wearing.