Alexis Dziena grew up in New York City and went to high school alongside her Bringing Rain (2003) costar, Paz de la Huerta. In addition to acting, Alexis Dziena is a budding playwright and drummer. When she's not writing or on set, Alexis Dziena can usually be found downtown, with her brother and boyfriend, dancing late into the night.

Alexis Dziena got her first acting job three years ago on an episode of TNT's Witchblade, and has been working steadily ever since. Alexis Dziena first came to prominence with a starring role in the 2004 Lifetime movie She's Too Young about sexually active and reckless teens, then had a cameo opposite her then-real-life boyfriend Michael Pittin Wonderland. Later this year Alexis Dziena tortures Amy Sedaris as a mean girl in the Strangers With Candy movie.

In 2005, Alexis Dziena played Lolita (a reference to Vladimir Nabokov's novel Lolita), a teenage girl, in Broken Flowers. Alexis Dziena appeared in scenes with Bill Murray and Sharon Stone Richard Roeper listed her performance as one of the five "Most startling nude scenes of the year" for 2005.